Complement Therapeutics in Autoimmune Disease

RNAi Therapeutics in Autoimmune Disease

Since the discovery of RNA interference (RNAi), excitement has grown over its potential therapeutic uses. Targeting RNAi pathways provides a powerful tool to change biological processes post-transcriptionally in various health conditions such as cancer or autoimmune diseases. Optimum design of shRNA, siRNA, and miRNA enhances stability and specificity of RNAi-based approaches whereas it has to ...

Complement-targeted therapeutics in periodontitis.

Periodontitis is a prevalent oral chronic inflammatory disease which, in severe forms, may exert a major impact on systemic health. Clinical and histological observations, as well as experimental animal studies, suggest involvement of the complement system in periodontitis. However, the precise roles of the various complement components and pathways in periodontitis have only recently started t...

PI3K inhibitors as potential therapeutics for autoimmune disease.

Aberrant overactivation of the immune system can give rise to chronic and persistent self-attack, culminating in autoimmune disease. This is currently managed therapeutically using potent immunosuppressive and anti-inflammatory drugs. Class I phosphoinositide 3-kinases (PI3Ks) have been identified as ideal therapeutic targets for autoimmune diseases given their wide-ranging roles in immunologic...

Indirect Complement Fixation in Foot-and-Mouth Disease

mannose-binding lectin mediated complement pathway in autoimmune neurological disorders

multiple sclerosis (ms) is a complex, demyelinating disease of the central nervous system (cns) with variable phenotypic presentations, while guillain-barre syndrome (gbs) is the prototypic acute inflammatory disorder that affects the peripheral nervous system. myasthenia gravis (mg) is a t cell dependent and antibody mediated autoimmune disease. although it has been shown that complement plays...